Summary 'Bone Morphogenetic Protein (BMP) Receptor Activators-Pipeline Insights, 2014', report provides comprehensive insights about pipeline drugs across this mechanism of action (MOA). A key objective of the report is to establish the ... Individual.com, 1 month ago
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Experimental issues : Nephron patterning is assessed using several parameters: maturation, segment length, protein expression and gene expression. The results of these distinct assessments are not explicitly compared and integrated into one ...Elifesciences, 3 weeks ago
Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation
Introduction Bone Morphogenetic Proteins (BMPs) represent a conserved family of secreted signalling proteins that regulate diverse processes during development and homeostasis ( Wu and Hill, 2009 ). Multiple tiers of regulation within the BMP ...Elifesciences, 3 weeks ago
Prodomain Removal Enables Neto to Stabilize Glutamate Receptors at the Drosophila Neuromuscular Junction
Abstract Stabilization of neurotransmitter receptors at postsynaptic specializations is a key step in the assembly of functional synapses. Drosophila Neto (Neuropillin and Tolloid-like protein) is an essential auxiliary subunit of ionotropic ...Plosone.org, 1 day ago
AAAS Annual Meeting 12-16 February, 2015 San Jose, California EurekAlert! provides embargoed and breaking science news you can't afford to miss. EurekAlert! offers a one-stop science news distribution service you can trust. EurekAlert! is a ...EurekAlert!, 2 days ago
The conference will explore the development of Latin America through three lenses: leadership in business and government, the societal demands of a burgeoning middle class, and the globalization of Latin American companies. Friday, March 06, ...UCLA International Institue, 3 days ago
Sandwich Allografts for Long-Bone Nonunions in Patients with Osteogenesis Imperfecta: A Retrospective Study
Abstract Background: Patients with osteogenesis imperfecta often develop nonunions, as internal fixation has limited applicability in this condition. We report the outcomes of a modified sandwich technique in the treatment of long-bone nonunions in ...Journal of Bone and Joint Surgery, 3 days ago
Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection
Abstract Background: Treatment of infected open fractures remains a major clinical challenge. In this study, we investigated the novel broad-spectrum antibiotic CSA-90 (cationic steroid antibiotic-90) as an antimicrobial agent. Methods: CSA-90 ...Journal of Bone and Joint Surgery, 3 days ago
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/.beta.-catenin signaling is first activated in pluripotent cells, e.g., by inhibition of Gsk-3 to obtain a first ...PharmCast, 4 days ago Methods for reprogramming somatic cells PharmCast, 4 weeks ago
Regulatory Story GAME Digital PLC - GMD Released 12:04 23-Feb-2015 RNS Number : 6121F GAME Digital PLC 23 February 2015 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer of existing shares to ...London Stock Exchange, 5 days ago
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