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About 32 results for "hcl axon"

Distinct and Cooperative Functions for the Protocadherin-α, -...

Introduction The clustered protocadherins (Pcdhs) are diverse cadherin-related receptors and constitute gene clusters in mammals ( Kohmura et al., 1998 ; Wu and Maniatis, 1999 ). The Pcdh genes are expressed in the central and peripheral nervous ... Frontiers in Neurorobotics, 1 month ago

Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1

Abstract The establishment of precise topographic maps during neural development is facilitated by the presorting of axons in the pathway before they reach their targets. In the vertebrate visual system, such topography is seen clearly in the ...
 Journal of Neuroscience1 month ago

Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice

Introduction The main olfactory epithelium (MOE) is a pseudostratified epithelial structure required for odor perception in mammals ( Beites et al., 2005 ). The neural stem cells located in the basal epithelium give rise to olfactory sensory ...
 Frontiers in Neurorobotics5 days ago

The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability

Introduction Myeloid cells such as microglia, dendritic cells, osteoclasts, and macrophages express triggering receptor expressed on myeloid cells-2 (TREM2) which belongs to the immunoglobulin superfamily. TREM2 is a type 1 membrane protein ...
 Frontiers in Neurorobotics6 days ago

MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Introduction Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline, neuronal/synaptic loss and neuroinflammation. The amyloidogenic hypothesis of the disease postulates that ...
 Frontiers in Neurorobotics2 weeks ago Human Neural Stem Cell Transplantation Rescues Cognitive Defects in APP/PS1 Model of Alzheimer's Disease by Enhancing Neuronal Connectivity and Metabolic Activity  Frontiers in Neurorobotics2 months ago

Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons

Introduction The γ-aminobutyric acid (GABA)-ergic interneurons are essential modulators of brain activity ( Gelman and Marín, 2010 ), and their abnormal maturation may alter the balance between excitatory and inhibitory brain activity leading to ...
 Frontiers in Neurorobotics1 month ago

SOD1 Lysine 123 Acetylation in the Adult Central Nervous System

Introduction Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide radicals to hydrogen peroxide and oxygen ( McCord and Fridovich, 1969 ). SOD1 is a predominantly cytoplasmic enzyme that is ubiquitously expressed, ...
 Frontiers in Neurorobotics1 month ago

Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis

Introduction The six members of the contactin family of immunoglobulin cell adhesion molecules (IgCAMs) play diverse roles in the nervous system ( Shimoda and Watanabe, 2009 ; Stoeckli, 2010 ; Zuko et al., 2013 ). Contactin-1 (Cntn, a.k.a. F3) and ...
 Frontiers in Neurorobotics1 month ago

HMG Strategy Recognizes IT Thought Leaders and Business Partners for the Success of its 2016 CIO Executive Leadership Summits, Highlights Exciting Developments for 2017

WESTPORT, Conn., Dec. 12, 2016 /PRNewswire/ -- Following record attendance at its 50-plus executive leadership events throughout 2016, HMG Strategy recognizes the IT executives, industry thought leaders, and business partners that helped make its ...
 International Business Times1 month ago

Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord

Introduction The natriuretic peptide (NP) family consists of atrial NP (ANP), brain NP (BNP) and C-type NP (CNP; Potter et al., 2009 ). Although BNP was originally discovered in the porcine brain, it is predominately produced from by the heart ...
 Frontiers in Neurorobotics1 month ago
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