The development of B-cellreceptor antagonists has been a therapeutic advance in chronic lymphocytic leukemia (CLL). Although B-cellreceptor ligation in normal cells induces proliferation, apoptosis, or anergy, 1 pathway dysregulation in CLL results ... New England Journal of Medicine, 1 month ago
Extracellular ATP Hydrolysis Inhibits Synaptic Transmission by Increasing pH Buffering in the Synaptic Cleft
Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors. This interaction generates the center/surround organization of bipolar cell ...PLoS Biology, 2 months ago
This study demonstrates two extraordinary forms of synaptic inhibition. HCs feed back negatively to cones via two mechanisms: a very fast Cx-hemichannel-mediated ephaptic mechanism with no synaptic delay and a relatively slow mechanism that ...PLoS Biology, 2 months ago
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