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About 800 results for "tyrosine"

Discovering the first tyrosine kinase [Biochemistry]

Tony Hunter 1 Salk Institute for Biological Studies , La Jolla, CA 92037-1002 Edited by Joseph Schlessinger, Yale University School of Medicine, New Haven, CT, and approved May 26, 2015 (received for review ... PNAS, 4 days ago

51 images for tyrosine

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[Comment] mutations and EGFR tyrosine kinase inhibitors

In 2004, three groups independently noted that the presence of activating mutations in patients with advanced non-small-cell lung cancer made tumours sensitive to EGFR tyrosine kinase inhibitors.1 Since then, nine randomised trials including almost ...
 Lancet Neurology6 days ago
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Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2), an Important Regulator of IL-6 Production in Rheumatoid Arthritis Synovial Fibroblasts

Abstract Objective This article is protected by copyright. All rights reserved. Methods Synovial tissues from RA and osteoarthritis (OA) were stained for PTPN2. Synovial fibroblasts (SF), were stimulated with TNF and IL1β, LPS, TRAIL or ...
 Arthritis & Rheumatism3 days ago A simple and visible colorimetric method through Zr4+-phosphate coordination for the assay of protein tyrosine phosphatase 1B and its inhibitor screening  RSC1 week ago Protein-Tyrosine Phosphatase 1B (PTP1B) Inhibitors -Pipeline Insights, 2015  RCL Advisors1 week ago Inactivation of Protein Tyrosine Phosphatases by Peracids Correlates with the Hydrocarbon Chain Length  Cellular Physiology and Biochemistry2 weeks ago
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ErbB Signaling Pathway in Cancer Drug Pipeline Update 2015

/PRNewswire/ -- The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell ...
 PR Newswire1 week ago Calcium Signaling Pathway in Cancer Drug Pipeline Update 2015  TickerTech.com3 days ago Cell Cycle Targeting in Cancer Drug Pipeline Update 2015  International Business Times3 days ago
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BeiGene Announces IND Approval for BGB-3111, a Bruton Tyrosine Kinase Inhibitor

)—BeiGene Ltd., an innovative oncology company focused on developing targeted and immune-oncology therapeutics, today announced that the United States Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application ...
 Drugs.com1 week ago
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Medical News Today

Bosutinib is well-suited for older patients with chronic myeloid leukemia

The tyrosine kinase inhibitor bosutinib appears to well-suited for chronic myeloid leukemia patients who are elderly and have multiple co-morbidities, according to results presented at the 20th Congress of the European Hematology Association. The ...
 Medical News Today1 day ago

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase

Takeda California, 10410 Science Center Drive, San Diego, California 92121,
 Journal of Medicinal Chemistry2 days ago

Wee1 Tyrosine Kinase inhibitors -Pipeline Insights

ID: 2976193 DelveInsight Summary Wee1 Tyrosine Kinase inhibitors- Pipeline Insights provides the in-depth analysis of the pipeline assets across the Wee1 Tyrosine Kinase inhibitors. The main objective of this report to track competitor ...
 Research and Markets3 days ago Non-Receptor Tyrosine Kinase Inhibitors -Pipeline Insights  Research and Markets3 days ago

JIANGSU HENGRUI MEDICINE : "Crystalline Form I of Tyrosine Kinase Inhibitor Dimaleate and Preparation Methods Thereof" in Patent Application Approval Process

By a News Reporter-Staff News Editor at Drug Week -- A patent application by the inventors Sun, Piaoyang (Lianyungang, CN); Wu, Guaili (Lianyungang, CN); Yuan, Bo (Lianyungang, CN); Chen, Yongjiang (Lianyungang, CN), filed on June 4, 2013 , was made ...
 4 Traders3 days ago AJINOMOTO : Patent Issued for Method for Producing Pyrroloquinoline Quinone Using a Bacterium of the Genus Methylobacterium Or Hyphomicrobium  4 Traders4 days ago

Role of EFNB1 and EFNB2 in Mouse Collagen-Induced Arthritis and Human Rheumatoid Arthritis

Objective EFNB1 and EFNB2 are ligands for Eph receptor tyrosine kinases. This study was undertaken to investigate how the expression of Efnb1 and Efnb2 on murine T cells influences the pathogenesis of collagen-induced arthritis (CIA) and to assess ...
 Arthritis & Rheumatism1 week ago
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