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About 786 results for "tyrosine"

Chaetocin synergistic with TKIs against CML cells

medwireNews: Chaetocin, a mycotoxin that increases oxidative stress, can complement the activity of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukaemia (CML) by overcoming innate resistance mediated by secreted bone marrow stromal ... MedWire News, 6 days ago

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No survival benefit with dacomitinib in pretreated patients with advanced NSCLC

medwireNews: The irreversible, pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) dacomitinib does not offer a survival benefit in pretreated patients with advanced or metastatic non-small-cell lung cancer (NSCLC), phase III ...
 MedWire News6 days ago
Med India

New Drug To Reduce Side Effects Of Modern Cancer Treatment

A new strategy to reduce the serious side effects of an important class of modern anticancer drugs (tyrosine kinase inhibitors) has been established jointly by an interdisciplinary team of researchers from the University of Vienna (Institute of Inorganic ...
 Med India1 month ago

Pharmacokineticpharmacodynamic modeling of fostamatinib efficacy on ACR20 to support dose selection in patients with rheumatoid arthritis (RA)

Abstract R788 (fostamatinib) is an oral prodrug that is rapidly converted into a relatively selective spleen tyrosine kinase (SYK) inhibitor R406, evaluated for the treatment of rheumatoid arthritis (RA). This analysis aimed at developing a ...
 Journal of Clinical Pharmacology12 hours ago
Med India

Continuing Tyrosine Kinase Inhibitor Therapy After Resistance Development in Lung Cancer

A phase III trial has shown that patients whose lung cancer has developed resistance to the drug gefitinib experience no statistically significant improvement in progression-free survival from continued treatment with the drug in addition to chemotherapy. The ...
 Med India1 month ago Trial results show treatment-resistant advanced non-small cell lung cancer responds to new drug, rociletinib  European Cancer Organisation2 days ago Trial Shows Treatment-resistant Advanced Non-small Cell ...  MedIndia1 day ago Treatment-resistant advanced non-small cell lung cancer responds to new drug, rociletinib  Ecancer Medicalscience2 days ago
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In Vivo Experiments Reveal the Good, the Bad and the Ugly Faces of sFlt-1 in Pregnancy

Abstract Objective Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human ...
 Plosone.org1 week ago

Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using TargetLigand Interaction-Based Virtual Screening

† Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China‡ Key Laboratory Experimental Teratology of the Ministry of Education and ...
 Journal of Medicinal Chemistry1 week ago

CD148 Tyrosine Phosphatase Promotes Cadherin Cell Adhesion

by Keiko Takahashi, Anton Matafonov, Katherine Sumarriva, Hideyuki Ito, Colette Lauhan, Dana Zemel, Nobuo Tsuboi, Jin Chen, Albert Reynolds, Takamune Takahashi CD148 is a transmembrane tyrosine phosphatase that is expressed at cell junctions.
 Plosone.org1 week ago

Bioinformatic Analysis Reveals Genome Size Reduction and the Emergence of Tyrosine Phosphorylation Site in the Movement Protein of New World Bipartite Begomoviruses

by Eric S. Ho, Joan Kuchie, Siobain Duffy Begomovirus (genus Begomovirus, family Geminiviridae ) infection is devastating to a wide variety of agricultural crops including tomato, squash, and cassava. Thus, understanding the replication and ...
 Plosone.org1 week ago

Intestinal Colonization by Candida albicans Alters Inflammatory Responses in Bruton's Tyrosine Kinase-Deficient Mice

by Karin Strijbis, Ömer H. Yilmaz, Stephanie K. Dougan, Alexandre Esteban, Andrea Gröne, Carol A. Kumamoto, Hidde L. Ploegh The commensal yeast Candida albicans is part of the human intestinal microflora and is considered a pathobiont, a resident ...
 Plosone.org1 week ago
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